Recurrent secondary genomic alterations in desmoplastic small round cell tumors.

Desmoplastic small round cell tumor (DSRCT) is a rare, highly aggressive, translocation-associated soft-tissue sarcoma that primarily affects children, adolescents, and young adults, with a striking male predominance. It is characterized by t(11;22) generating a novel EWSR1-WT1 fusion gene. Secondary genomic alterations are rarely described.Tumor tissue from 83 DSRCT patients was assayed by hybrid-capture based comprehensive genomic profiling, FoundationOne Heme next generation sequencing analysis of 406 genes and RNA sequencing of 265 genes.

Tumor mutation burden was calculated from a minimum of 1.4 Mb sequenced DNA. Microsatellite instability status was determined by a novel algorithm analyzing 114 specific loci.Comprehensive genomic profiling identified several genomically-defined DSRCT subgroups.

Recurrent genomic alterations were most frequently detected in FGFR4, ARID1A, TP53, MSH3, and MLL3 genes. With the exception of FGFR4, where the genomic alterations predicted activation, most of the alterations in the remaining genes predicted gene inactivation.

No DSRCT were TMB or MSI high.In summary, recurrent secondary somatic alterations in FGFR4, ARID1A, TP53, MSH3, and MLL3 were detected in 82% of DSRCT, which is significantly greater than previously reported. These alterations may have both prognostic and therapeutic implications.

11-Hydroxyprogesterone (11-OHP) Antibody
20-abx102405	Abbexa	EUR 425.00 EUR 133.00 EUR 1177.00 EUR 578.00 EUR 328.00	100 ug 10 ug 1 mg 200 ug 50 ug

Kallikrein 11 (Kallikrein 11) Antibody
20-abx007794	Abbexa	EUR 300.00 EUR 439.00 EUR 189.00	100 ul 200 ul 30 ul

Kallikrein 11 (Kallikrein 11) Antibody
20-abx008292	Abbexa	EUR 300.00 EUR 439.00 EUR 189.00	100 ul 200 ul 30 ul

Syntaxin 11 (Syntaxin 11) Antibody
abx431886-200ul	Abbexa	200 ul	EUR 384

Syntaxin 11 (Syntaxin 11) Antibody
abx238445-100ug	Abbexa	100 ug	EUR 509

Kallikrein 11 (Kallikrein 11) Antibody
abx234457-100ug	Abbexa	100 ug	EUR 481

Calpain 11 (Calpain 11) Antibody
abx231212-100ug	Abbexa	100 ug	EUR 481

Recombinant Human Growth Dfferentiation Factor 11/GDF-11/BMP-11
C799-10ug	Novoprotein	10ug	EUR 202
Description: Lyophilized from a 0.2 μm filtered solution of PBS,pH7.4.

Recombinant Human Growth Dfferentiation Factor 11/GDF-11/BMP-11
C799-1mg	Novoprotein	1mg	EUR 2486
Description: Lyophilized from a 0.2 μm filtered solution of PBS,pH7.4.

Recombinant Human Growth Dfferentiation Factor 11/GDF-11/BMP-11
C799-500ug	Novoprotein	500ug	EUR 1613
Description: Lyophilized from a 0.2 μm filtered solution of PBS,pH7.4.

Recombinant Human Growth Dfferentiation Factor 11/GDF-11/BMP-11
C799-50ug	Novoprotein	50ug	EUR 496
Description: Lyophilized from a 0.2 μm filtered solution of PBS,pH7.4.

CA125 (Cancer antigen) ELISA test
11	Biobase	96T/Box	Ask for price
Description: ELISA based test for quantitative detection of CA125 (Cancer antigen)

BSA Conjugated 11-Hydroxyprogesterone (11-OHP)
4-CPK517Ge11	Cloud-Clone	EUR 429.73 EUR 218.00 EUR 1336.48 EUR 512.16 EUR 924.32 EUR 350.00 EUR 3191.20	100 ug 10ug 1 mg 200 ug 500 ug 50ug 5 mg
Description: Recombinant Pan-species 11-Hydroxyprogesterone expressed in: chemical synthesis

OVA Conjugated 11-Hydroxyprogesterone (11-OHP)
4-CPK517Ge21	Cloud-Clone	EUR 494.24 EUR 235.00 EUR 1578.40 EUR 592.80 EUR 1085.60 EUR 394.00 EUR 3796.00	100 ug 10ug 1 mg 200 ug 500 ug 50ug 5 mg
Description: Recombinant Pan-species 11-Hydroxyprogesterone expressed in: chemical synthesis

IL-11, Interleukin-11, murine (mouse)
RC232-22	Bio Basic	2ug	EUR 104.38

IL-11 (Interleukin 11) GMP, CF
PR15133CF	Neuromics	50 ug	EUR 3755

Bay 11-7821(BAY 11-7082)
A4210-10	ApexBio	10 mg	EUR 119
Description: Bay 11-7821(Bay 11-7082) is an inhibitor of IKK with IC50 value of 10?M [1].Bay 11-7821 inhibits the TNF?-induced phosphorylation of I?B-?, results in an inhibition of NF-?B.

Bay 11-7821(BAY 11-7082)
A4210-100	ApexBio	100 mg	EUR 398
Description: Bay 11-7821(Bay 11-7082) is an inhibitor of IKK with IC50 value of 10?M [1].Bay 11-7821 inhibits the TNF?-induced phosphorylation of I?B-?, results in an inhibition of NF-?B.

Bay 11-7821(BAY 11-7082)
A4210-25	ApexBio	25 mg	EUR 189
Description: Bay 11-7821(Bay 11-7082) is an inhibitor of IKK with IC50 value of 10?M [1].Bay 11-7821 inhibits the TNF?-induced phosphorylation of I?B-?, results in an inhibition of NF-?B.

Bay 11-7821(BAY 11-7082)
A4210-50	ApexBio	50 mg	EUR 270
Description: Bay 11-7821(Bay 11-7082) is an inhibitor of IKK with IC50 value of 10?M [1].Bay 11-7821 inhibits the TNF?-induced phosphorylation of I?B-?, results in an inhibition of NF-?B.

Recombinant Human Interleukin-11/IL-11
C006-10ug	Novoprotein	10ug	EUR 202
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 2% Glycine, pH 7.2.

Recombinant Human Interleukin-11/IL-11
C006-1mg	Novoprotein	1mg	EUR 1836
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 2% Glycine, pH 7.2.

Recombinant Human Interleukin-11/IL-11
C006-500ug	Novoprotein	500ug	EUR 1298
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 2% Glycine, pH 7.2.

Recombinant Human Interleukin-11/IL-11
C006-50ug	Novoprotein	50ug	EUR 496
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 2% Glycine, pH 7.2.

BMP-11/GDF-11, human recombinant
7155-10	Biovision		EUR 240

BMP-11/GDF-11, human recombinant
7155-50	Biovision		EUR 860

FX-11
HY-16214	MedChemExpress	10mM/1mL	EUR 201

BT-11
HY-102013	MedChemExpress	100mg	EUR 911

IL-11
E21-006	EnoGene	10ug	EUR 343

Kallikrein 11
MO15030	Neuromics	100 ug	EUR 318

Kallikrein 11
GT15082	Neuromics	100 ug	EUR 500

VDM 11
B6717-10	ApexBio	10 mg	EUR 137

VDM 11
B6717-25	ApexBio	25 mg	EUR 257

VDM 11
B6717-50	ApexBio	50 mg	EUR 416

LF 11
B5589-1	ApexBio	1 mg	EUR 334

Y 11
B5621-10	ApexBio	10 mg	EUR 221

Y 11
B5621-25	ApexBio	25 mg	EUR 415

Y 11
B5621-5	ApexBio	5 mg	EUR 147

PDM 11
C5225-100	ApexBio	100 mg	EUR 273
Description: PDM 11 is a potent and selective aryl hydrocarbon receptor (AhR) antagonist.Aryl hydrocarbon receptor (AhR), a ligand-dependent intracellular transcription factor, has ligands including the most infamous xenobiotics, such as benzo[a]pyrene, dioxin, and plenty of polyaromatics.

PDM 11
C5225-25	ApexBio	25 mg	EUR 116
Description: PDM 11 is a potent and selective aryl hydrocarbon receptor (AhR) antagonist.Aryl hydrocarbon receptor (AhR), a ligand-dependent intracellular transcription factor, has ligands including the most infamous xenobiotics, such as benzo[a]pyrene, dioxin, and plenty of polyaromatics.

PDM 11
C5225-50	ApexBio	50 mg	EUR 174
Description: PDM 11 is a potent and selective aryl hydrocarbon receptor (AhR) antagonist.Aryl hydrocarbon receptor (AhR), a ligand-dependent intracellular transcription factor, has ligands including the most infamous xenobiotics, such as benzo[a]pyrene, dioxin, and plenty of polyaromatics.

QS 11
B7364-10	ApexBio	10 mg	EUR 311
Description: EC50: 1.5 ?M for ARFGAP1 enzymatic assay [1] and 0.5 ?M for Wnt synergist [2]Purine derivative QS11 is a Wnt synergistic agonist by inhibiting the GTPase activating protein of ADP-ribosylation factor 1 (ARFGAP1).

QS 11
B7364-25	ApexBio	25 mg	EUR 659
Description: EC50: 1.5 ?M for ARFGAP1 enzymatic assay [1] and 0.5 ?M for Wnt synergist [2]Purine derivative QS11 is a Wnt synergistic agonist by inhibiting the GTPase activating protein of ADP-ribosylation factor 1 (ARFGAP1).

QS 11
B7364-5	ApexBio	5 mg	EUR 206
Description: EC50: 1.5 ?M for ARFGAP1 enzymatic assay [1] and 0.5 ?M for Wnt synergist [2]Purine derivative QS11 is a Wnt synergistic agonist by inhibiting the GTPase activating protein of ADP-ribosylation factor 1 (ARFGAP1).

SF 11
B7528-10	ApexBio	10 mg	EUR 389

SF 11
B7528-50	ApexBio	50 mg	EUR 1476

11-Methoxytubotaiwine
TBZ0605	ChemNorm	unit	Ask for price

11-methoxyyangonin
TBZ3018	ChemNorm	unit	Ask for price

11-Hydroxygelsenicine
TTE1301	ChemNorm	unit	Ask for price

11-Hydroxyhumantenine
TTE1302	ChemNorm	unit	Ask for price

11-Hydroxyrankinidine
TTE1303	ChemNorm	unit	Ask for price

11-Hydroxytephrosin
TTE1304	ChemNorm	unit	Ask for price

AKP-11
B1973-25	Biovision		EUR 805

AKP-11
B1973-5	Biovision		EUR 240

11-Hydroxyprogesterone (11-OHP) Polyclonal Antibody (General)
4-PAK517Ge01	Cloud-Clone	EUR 242.00 EUR 2444.00 EUR 610.00 EUR 304.00 EUR 212.00	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against General 11-Hydroxyprogesterone (11-OHP)

Human Interleukin 11, IL-11 ELISA KIT
CSB-E04596h-24T	Cusabio	1 plate of 24 wells	EUR 165
Description: Quantitativesandwich ELISA kit for measuring Human Interleukin 11, IL-11 in samples from serum, cell culture supernates, urine, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Human Interleukin 11, IL-11 ELISA KIT
1-CSB-E04596h	Cusabio	EUR 602.00 EUR 4238.00 EUR 2256.00	1 plate of 96 wells 10 plates of 96 wells each 5 plates of 96 wells each
Description: Quantitativesandwich ELISA kit for measuring Human Interleukin 11, IL-11 in samples from serum, cell culture supernates, urine, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Mouse Interleukin 11, IL-11 ELISA KIT
CSB-E04597m-24T	Cusabio	1 plate of 24 wells	EUR 165
Description: Quantitativesandwich ELISA kit for measuring Mouse Interleukin 11, IL-11 in samples from serum, plasma, cell culture supernates, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Mouse Interleukin 11, IL-11 ELISA KIT
1-CSB-E04597m	Cusabio	EUR 603.00 EUR 4247.00 EUR 2260.00	1 plate of 96 wells 10 plates of 96 wells each 5 plates of 96 wells each
Description: Quantitativesandwich ELISA kit for measuring Mouse Interleukin 11, IL-11 in samples from serum, plasma, cell culture supernates, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Rat Interleukin 11, IL-11 ELISA KIT
CSB-E07358r-24T	Cusabio	1 plate of 24 wells	EUR 165
Description: Quantitativesandwich ELISA kit for measuring Rat Interleukin 11, IL-11 in samples from serum, plasma, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Rat Interleukin 11, IL-11 ELISA KIT
1-CSB-E07358r	Cusabio	EUR 703.00 EUR 4843.00 EUR 2570.00	1 plate of 96 wells 10 plates of 96 wells each 5 plates of 96 wells each
Description: Quantitativesandwich ELISA kit for measuring Rat Interleukin 11, IL-11 in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

IL-11 Interleukin-11 Mouse Recombinant Protein
PROTP47873	BosterBio	Regular: 10ug	EUR 317
Description: Interleukin-11 Mouse Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 179 amino acids and having a molecular mass of 19.1kDa. ;The Mouse IL-11 is purified by proprietary chromatographic techniques.

Rat Interleukin 11(IL-11)ELISA Kit
GA-E0118RT-48T	GenAsia Biotech	48T	EUR 317

Rat Interleukin 11(IL-11)ELISA Kit
GA-E0118RT-96T	GenAsia Biotech	96T	EUR 496

Human Interleukin 11(IL-11)ELISA Kit
GA-E0141HM-48T	GenAsia Biotech	48T	EUR 289

Human Interleukin 11(IL-11)ELISA Kit
GA-E0141HM-96T	GenAsia Biotech	96T	EUR 466

Human Kallikrein 11(KLK 11)ELISA Kit
GA-E0799HM-48T	GenAsia Biotech	48T	EUR 289

Human Kallikrein 11(KLK 11)ELISA Kit
GA-E0799HM-96T	GenAsia Biotech	96T	EUR 466

Mouse Interleukin 11(IL-11)ELISA Kit
GA-E0043MS-48T	GenAsia Biotech	48T	EUR 336

Mouse Interleukin 11(IL-11)ELISA Kit
GA-E0043MS-96T	GenAsia Biotech	96T	EUR 534

IL-11 Interleukin-11 Human Recombinant Protein
PROTP20809-1	BosterBio	Regular: 10ug	EUR 317
Description: Interleukin-11 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 179 amino acids and having a molecular mass of 19256.29 Dalton. ;The IL-11 is purified by proprietary chromatographic techniques.

Human Kallikrein 11,KLK 11 ELISA Kit
201-12-0783	SunredBio	96 tests	EUR 440
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids.

Human Interleukin 11,IL-11 ELISA KIT
201-12-0102	SunredBio	96 tests	EUR 440
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids.

Kinetoplastid Membrane Protein 11 (KMP-11) Antibody
abx415771-05ml	Abbexa	0.5 ml	EUR 899

Human Interleukin 11 (IL-11) CLIA Kit
abx197185-96tests	Abbexa	96 tests	EUR 825

Mouse Interleukin 11 (IL-11) CLIA Kit
abx197186-96tests	Abbexa	96 tests	EUR 825

Rat Interleukin 11 (IL-11) CLIA Kit
abx197187-96tests	Abbexa	96 tests	EUR 825

Human Syntaxin 11 (Syntaxin 11) ELISA Kit
abx259864-96tests	Abbexa	96 tests	EUR 911

Rat IL-11(Interleukin-11) ELISA Kit
ER0093	FN Test	96T	EUR 524.1
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Rattus;Sensitivity: 9.375pg/ml

Rat Interleukin 11(IL-11)ELISA Kit
QY-E11535	Qayee Biotechnology	96T	EUR 361

Goat Kallikrein 11,KLK 11 ELISA KIT
QY-E140025	Qayee Biotechnology	96T	EUR 413

Mouse Interleukin 11(IL-11)ELISA Kit
QY-E20831	Qayee Biotechnology	96T	EUR 361

Human Kallikrein 11(KLK 11)ELISA Kit
QY-E02953	Qayee Biotechnology	96T	EUR 361

Human Interleukin 11(IL-11)ELISA Kit
QY-E04330	Qayee Biotechnology	96T	EUR 400

Mouse WNT-11(WNT-11) ELISA Kit
EM0018	FN Test	96T	EUR 524.1
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Mus ;Sensitivity: 18.75pg/ml

Mouse Il-11(Interleukin-11) ELISA Kit
EM0225	FN Test	96T	EUR 524.1
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Mus ;Sensitivity: 9.375pg/ml

Human IL-11(Interleukin 11) ELISA Kit
EH0174	FN Test	96T	EUR 476.25
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Homo sapiens;Sensitivity: 18.75pg/ml

Mouse Interleukin 11,IL-11 ELISA KIT
CN-02458M1	ChemNorm	96T	EUR 447

Mouse Interleukin 11,IL-11 ELISA KIT
CN-02458M2	ChemNorm	48T	EUR 296

Human Interleukin 11,IL-11 ELISA KIT
CN-03220H1	ChemNorm	96T	EUR 434

Human Interleukin 11,IL-11 ELISA KIT
CN-03220H2	ChemNorm	48T	EUR 284

Human Kallikrein 11,KLK 11 ELISA Kit
CN-03728H1	ChemNorm	96T	EUR 470

Human Kallikrein 11,KLK 11 ELISA Kit
CN-03728H2	ChemNorm	48T	EUR 320

Rat Interleukin 11,IL-11 ELISA KIT
CN-01551R1	ChemNorm	96T	EUR 449

Rat Interleukin 11,IL-11 ELISA KIT
CN-01551R2	ChemNorm	48T	EUR 299

IL-11/ Rat IL- 11 ELISA Kit
ELA-E0057r	Lifescience Market	96 Tests	EUR 886