Desmoplastic small round cell tumor (DSRCT) is a rare, highly aggressive, translocation-associated soft-tissue sarcoma that primarily affects children, adolescents, and young adults, with a striking male predominance. It is characterized by t(11;22) generating a novel EWSR1-WT1 fusion gene. Secondary genomic alterations are rarely described.Tumor tissue from 83 DSRCT patients was assayed by hybrid-capture based comprehensive genomic profiling, FoundationOne Heme next generation sequencing analysis of 406 genes and RNA sequencing of 265 genes.
Tumor mutation burden was calculated from a minimum of 1.4 Mb sequenced DNA. Microsatellite instability status was determined by a novel algorithm analyzing 114 specific loci.Comprehensive genomic profiling identified several genomically-defined DSRCT subgroups.
Recurrent genomic alterations were most frequently detected in FGFR4, ARID1A, TP53, MSH3, and MLL3 genes. With the exception of FGFR4, where the genomic alterations predicted activation, most of the alterations in the remaining genes predicted gene inactivation.
No DSRCT were TMB or MSI high.In summary, recurrent secondary somatic alterations in FGFR4, ARID1A, TP53, MSH3, and MLL3 were detected in 82% of DSRCT, which is significantly greater than previously reported. These alterations may have both prognostic and therapeutic implications.
11-Hydroxyprogesterone (11-OHP) Antibody |
20-abx102405 |
Abbexa |
-
EUR 425.00
-
EUR 133.00
-
EUR 1177.00
-
EUR 578.00
-
EUR 328.00
|
- 100 ug
- 10 ug
- 1 mg
- 200 ug
- 50 ug
|
|
Kallikrein 11 (Kallikrein 11) Antibody |
20-abx007794 |
Abbexa |
-
EUR 300.00
-
EUR 439.00
-
EUR 189.00
|
|
|
Kallikrein 11 (Kallikrein 11) Antibody |
20-abx008292 |
Abbexa |
-
EUR 300.00
-
EUR 439.00
-
EUR 189.00
|
|
|
Syntaxin 11 (Syntaxin 11) Antibody |
abx431886-200ul |
Abbexa |
200 ul |
EUR 384 |
|
Syntaxin 11 (Syntaxin 11) Antibody |
abx238445-100ug |
Abbexa |
100 ug |
EUR 509 |
|
Kallikrein 11 (Kallikrein 11) Antibody |
abx234457-100ug |
Abbexa |
100 ug |
EUR 481 |
|
Calpain 11 (Calpain 11) Antibody |
abx231212-100ug |
Abbexa |
100 ug |
EUR 481 |
|
Recombinant Human Growth Dfferentiation Factor 11/GDF-11/BMP-11 |
C799-10ug |
Novoprotein |
10ug |
EUR 202 |
Description: Lyophilized from a 0.2 μm filtered solution of PBS,pH7.4. |
Recombinant Human Growth Dfferentiation Factor 11/GDF-11/BMP-11 |
C799-1mg |
Novoprotein |
1mg |
EUR 2486 |
Description: Lyophilized from a 0.2 μm filtered solution of PBS,pH7.4. |
Recombinant Human Growth Dfferentiation Factor 11/GDF-11/BMP-11 |
C799-500ug |
Novoprotein |
500ug |
EUR 1613 |
Description: Lyophilized from a 0.2 μm filtered solution of PBS,pH7.4. |
Recombinant Human Growth Dfferentiation Factor 11/GDF-11/BMP-11 |
C799-50ug |
Novoprotein |
50ug |
EUR 496 |
Description: Lyophilized from a 0.2 μm filtered solution of PBS,pH7.4. |
CA125 (Cancer antigen) ELISA test |
11 |
Biobase |
96T/Box |
Ask for price |
|
Description: ELISA based test for quantitative detection of CA125 (Cancer antigen) |
BSA Conjugated 11-Hydroxyprogesterone (11-OHP) |
4-CPK517Ge11 |
Cloud-Clone |
-
EUR 429.73
-
EUR 218.00
-
EUR 1336.48
-
EUR 512.16
-
EUR 924.32
-
EUR 350.00
-
EUR 3191.20
|
- 100 ug
- 10ug
- 1 mg
- 200 ug
- 500 ug
- 50ug
- 5 mg
|
|
Description: Recombinant Pan-species 11-Hydroxyprogesterone expressed in: chemical synthesis |
OVA Conjugated 11-Hydroxyprogesterone (11-OHP) |
4-CPK517Ge21 |
Cloud-Clone |
-
EUR 494.24
-
EUR 235.00
-
EUR 1578.40
-
EUR 592.80
-
EUR 1085.60
-
EUR 394.00
-
EUR 3796.00
|
- 100 ug
- 10ug
- 1 mg
- 200 ug
- 500 ug
- 50ug
- 5 mg
|
|
Description: Recombinant Pan-species 11-Hydroxyprogesterone expressed in: chemical synthesis |
IL-11, Interleukin-11, murine (mouse) |
RC232-22 |
Bio Basic |
2ug |
EUR 104.38 |
|
IL-11 (Interleukin 11) GMP, CF |
PR15133CF |
Neuromics |
50 ug |
EUR 3755 |
Bay 11-7821(BAY 11-7082) |
A4210-10 |
ApexBio |
10 mg |
EUR 119 |
Description: Bay 11-7821(Bay 11-7082) is an inhibitor of IKK with IC50 value of 10?M [1].Bay 11-7821 inhibits the TNF?-induced phosphorylation of I?B-?, results in an inhibition of NF-?B. |
Bay 11-7821(BAY 11-7082) |
A4210-100 |
ApexBio |
100 mg |
EUR 398 |
Description: Bay 11-7821(Bay 11-7082) is an inhibitor of IKK with IC50 value of 10?M [1].Bay 11-7821 inhibits the TNF?-induced phosphorylation of I?B-?, results in an inhibition of NF-?B. |
Bay 11-7821(BAY 11-7082) |
A4210-25 |
ApexBio |
25 mg |
EUR 189 |
Description: Bay 11-7821(Bay 11-7082) is an inhibitor of IKK with IC50 value of 10?M [1].Bay 11-7821 inhibits the TNF?-induced phosphorylation of I?B-?, results in an inhibition of NF-?B. |
Bay 11-7821(BAY 11-7082) |
A4210-50 |
ApexBio |
50 mg |
EUR 270 |
Description: Bay 11-7821(Bay 11-7082) is an inhibitor of IKK with IC50 value of 10?M [1].Bay 11-7821 inhibits the TNF?-induced phosphorylation of I?B-?, results in an inhibition of NF-?B. |
Recombinant Human Interleukin-11/IL-11 |
C006-10ug |
Novoprotein |
10ug |
EUR 202 |
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 2% Glycine, pH 7.2. |
Recombinant Human Interleukin-11/IL-11 |
C006-1mg |
Novoprotein |
1mg |
EUR 1836 |
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 2% Glycine, pH 7.2. |
Recombinant Human Interleukin-11/IL-11 |
C006-500ug |
Novoprotein |
500ug |
EUR 1298 |
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 2% Glycine, pH 7.2. |
Recombinant Human Interleukin-11/IL-11 |
C006-50ug |
Novoprotein |
50ug |
EUR 496 |
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 2% Glycine, pH 7.2. |
BMP-11/GDF-11, human recombinant |
7155-10 |
Biovision |
|
EUR 240 |
BMP-11/GDF-11, human recombinant |
7155-50 |
Biovision |
|
EUR 860 |
Kallikrein 11 |
MO15030 |
Neuromics |
100 ug |
EUR 318 |
Kallikrein 11 |
GT15082 |
Neuromics |
100 ug |
EUR 500 |
VDM 11 |
B6717-10 |
ApexBio |
10 mg |
EUR 137 |
VDM 11 |
B6717-25 |
ApexBio |
25 mg |
EUR 257 |
VDM 11 |
B6717-50 |
ApexBio |
50 mg |
EUR 416 |
Y 11 |
B5621-10 |
ApexBio |
10 mg |
EUR 221 |
Y 11 |
B5621-25 |
ApexBio |
25 mg |
EUR 415 |
PDM 11 |
C5225-100 |
ApexBio |
100 mg |
EUR 273 |
Description: PDM 11 is a potent and selective aryl hydrocarbon receptor (AhR) antagonist.Aryl hydrocarbon receptor (AhR), a ligand-dependent intracellular transcription factor, has ligands including the most infamous xenobiotics, such as benzo[a]pyrene, dioxin, and plenty of polyaromatics. |
PDM 11 |
C5225-25 |
ApexBio |
25 mg |
EUR 116 |
Description: PDM 11 is a potent and selective aryl hydrocarbon receptor (AhR) antagonist.Aryl hydrocarbon receptor (AhR), a ligand-dependent intracellular transcription factor, has ligands including the most infamous xenobiotics, such as benzo[a]pyrene, dioxin, and plenty of polyaromatics. |
PDM 11 |
C5225-50 |
ApexBio |
50 mg |
EUR 174 |
Description: PDM 11 is a potent and selective aryl hydrocarbon receptor (AhR) antagonist.Aryl hydrocarbon receptor (AhR), a ligand-dependent intracellular transcription factor, has ligands including the most infamous xenobiotics, such as benzo[a]pyrene, dioxin, and plenty of polyaromatics. |
QS 11 |
B7364-10 |
ApexBio |
10 mg |
EUR 311 |
Description: EC50: 1.5 ?M for ARFGAP1 enzymatic assay [1] and 0.5 ?M for Wnt synergist [2]Purine derivative QS11 is a Wnt synergistic agonist by inhibiting the GTPase activating protein of ADP-ribosylation factor 1 (ARFGAP1). |
QS 11 |
B7364-25 |
ApexBio |
25 mg |
EUR 659 |
Description: EC50: 1.5 ?M for ARFGAP1 enzymatic assay [1] and 0.5 ?M for Wnt synergist [2]Purine derivative QS11 is a Wnt synergistic agonist by inhibiting the GTPase activating protein of ADP-ribosylation factor 1 (ARFGAP1). |
QS 11 |
B7364-5 |
ApexBio |
5 mg |
EUR 206 |
Description: EC50: 1.5 ?M for ARFGAP1 enzymatic assay [1] and 0.5 ?M for Wnt synergist [2]Purine derivative QS11 is a Wnt synergistic agonist by inhibiting the GTPase activating protein of ADP-ribosylation factor 1 (ARFGAP1). |
SF 11 |
B7528-10 |
ApexBio |
10 mg |
EUR 389 |
SF 11 |
B7528-50 |
ApexBio |
50 mg |
EUR 1476 |
11-Methoxytubotaiwine |
TBZ0605 |
ChemNorm |
unit |
Ask for price |
11-methoxyyangonin |
TBZ3018 |
ChemNorm |
unit |
Ask for price |
11-Hydroxygelsenicine |
TTE1301 |
ChemNorm |
unit |
Ask for price |
11-Hydroxyhumantenine |
TTE1302 |
ChemNorm |
unit |
Ask for price |
11-Hydroxyrankinidine |
TTE1303 |
ChemNorm |
unit |
Ask for price |
11-Hydroxytephrosin |
TTE1304 |
ChemNorm |
unit |
Ask for price |
11-Hydroxyprogesterone (11-OHP) Polyclonal Antibody (General) |
4-PAK517Ge01 |
Cloud-Clone |
-
EUR 242.00
-
EUR 2444.00
-
EUR 610.00
-
EUR 304.00
-
EUR 212.00
|
- 100ul
- 10ml
- 1ml
- 200ul
- 20ul
|
|
Description: A Rabbit polyclonal antibody against General 11-Hydroxyprogesterone (11-OHP) |
Human Interleukin 11, IL-11 ELISA KIT |
CSB-E04596h-24T |
Cusabio |
1 plate of 24 wells |
EUR 165 |
|
Description: Quantitativesandwich ELISA kit for measuring Human Interleukin 11, IL-11 in samples from serum, cell culture supernates, urine, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price. |
Human Interleukin 11, IL-11 ELISA KIT |
1-CSB-E04596h |
Cusabio |
-
EUR 602.00
-
EUR 4238.00
-
EUR 2256.00
|
- 1 plate of 96 wells
- 10 plates of 96 wells each
- 5 plates of 96 wells each
|
|
Description: Quantitativesandwich ELISA kit for measuring Human Interleukin 11, IL-11 in samples from serum, cell culture supernates, urine, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits. |
Mouse Interleukin 11, IL-11 ELISA KIT |
CSB-E04597m-24T |
Cusabio |
1 plate of 24 wells |
EUR 165 |
|
Description: Quantitativesandwich ELISA kit for measuring Mouse Interleukin 11, IL-11 in samples from serum, plasma, cell culture supernates, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price. |
Mouse Interleukin 11, IL-11 ELISA KIT |
1-CSB-E04597m |
Cusabio |
-
EUR 603.00
-
EUR 4247.00
-
EUR 2260.00
|
- 1 plate of 96 wells
- 10 plates of 96 wells each
- 5 plates of 96 wells each
|
|
Description: Quantitativesandwich ELISA kit for measuring Mouse Interleukin 11, IL-11 in samples from serum, plasma, cell culture supernates, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits. |
Rat Interleukin 11, IL-11 ELISA KIT |
CSB-E07358r-24T |
Cusabio |
1 plate of 24 wells |
EUR 165 |
|
Description: Quantitativesandwich ELISA kit for measuring Rat Interleukin 11, IL-11 in samples from serum, plasma, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price. |
Rat Interleukin 11, IL-11 ELISA KIT |
1-CSB-E07358r |
Cusabio |
-
EUR 703.00
-
EUR 4843.00
-
EUR 2570.00
|
- 1 plate of 96 wells
- 10 plates of 96 wells each
- 5 plates of 96 wells each
|
|
Description: Quantitativesandwich ELISA kit for measuring Rat Interleukin 11, IL-11 in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits. |
IL-11 Interleukin-11 Mouse Recombinant Protein |
PROTP47873 |
BosterBio |
Regular: 10ug |
EUR 317 |
Description: Interleukin-11 Mouse Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 179 amino acids and having a molecular mass of 19.1kDa. ;The Mouse IL-11 is purified by proprietary chromatographic techniques. |
Rat Interleukin 11(IL-11)ELISA Kit |
GA-E0118RT-48T |
GenAsia Biotech |
48T |
EUR 317 |
Rat Interleukin 11(IL-11)ELISA Kit |
GA-E0118RT-96T |
GenAsia Biotech |
96T |
EUR 496 |
Human Interleukin 11(IL-11)ELISA Kit |
GA-E0141HM-48T |
GenAsia Biotech |
48T |
EUR 289 |
Human Interleukin 11(IL-11)ELISA Kit |
GA-E0141HM-96T |
GenAsia Biotech |
96T |
EUR 466 |
Human Kallikrein 11(KLK 11)ELISA Kit |
GA-E0799HM-48T |
GenAsia Biotech |
48T |
EUR 289 |
Human Kallikrein 11(KLK 11)ELISA Kit |
GA-E0799HM-96T |
GenAsia Biotech |
96T |
EUR 466 |
Mouse Interleukin 11(IL-11)ELISA Kit |
GA-E0043MS-48T |
GenAsia Biotech |
48T |
EUR 336 |
Mouse Interleukin 11(IL-11)ELISA Kit |
GA-E0043MS-96T |
GenAsia Biotech |
96T |
EUR 534 |
IL-11 Interleukin-11 Human Recombinant Protein |
PROTP20809-1 |
BosterBio |
Regular: 10ug |
EUR 317 |
Description: Interleukin-11 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 179 amino acids and having a molecular mass of 19256.29 Dalton. ;The IL-11 is purified by proprietary chromatographic techniques. |
Human Kallikrein 11,KLK 11 ELISA Kit |
201-12-0783 |
SunredBio |
96 tests |
EUR 440 |
|
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids. |
Human Interleukin 11,IL-11 ELISA KIT |
201-12-0102 |
SunredBio |
96 tests |
EUR 440 |
|
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids. |
Kinetoplastid Membrane Protein 11 (KMP-11) Antibody |
abx415771-05ml |
Abbexa |
0.5 ml |
EUR 899 |
|
Human Interleukin 11 (IL-11) CLIA Kit |
abx197185-96tests |
Abbexa |
96 tests |
EUR 825 |
|
Mouse Interleukin 11 (IL-11) CLIA Kit |
abx197186-96tests |
Abbexa |
96 tests |
EUR 825 |
|
Rat Interleukin 11 (IL-11) CLIA Kit |
abx197187-96tests |
Abbexa |
96 tests |
EUR 825 |
|
Human Syntaxin 11 (Syntaxin 11) ELISA Kit |
abx259864-96tests |
Abbexa |
96 tests |
EUR 911 |
|
Rat IL-11(Interleukin-11) ELISA Kit |
ER0093 |
FN Test |
96T |
EUR 524.1 |
|
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Rattus;Sensitivity: 9.375pg/ml |
Mouse WNT-11(WNT-11) ELISA Kit |
EM0018 |
FN Test |
96T |
EUR 524.1 |
|
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Mus ;Sensitivity: 18.75pg/ml |
Mouse Il-11(Interleukin-11) ELISA Kit |
EM0225 |
FN Test |
96T |
EUR 524.1 |
|
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Mus ;Sensitivity: 9.375pg/ml |
Human IL-11(Interleukin 11) ELISA Kit |
EH0174 |
FN Test |
96T |
EUR 476.25 |
|
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Homo sapiens;Sensitivity: 18.75pg/ml |
Mouse Interleukin 11,IL-11 ELISA KIT |
CN-02458M1 |
ChemNorm |
96T |
EUR 447 |
Mouse Interleukin 11,IL-11 ELISA KIT |
CN-02458M2 |
ChemNorm |
48T |
EUR 296 |
Human Interleukin 11,IL-11 ELISA KIT |
CN-03220H1 |
ChemNorm |
96T |
EUR 434 |
Human Interleukin 11,IL-11 ELISA KIT |
CN-03220H2 |
ChemNorm |
48T |
EUR 284 |
Human Kallikrein 11,KLK 11 ELISA Kit |
CN-03728H1 |
ChemNorm |
96T |
EUR 470 |
Human Kallikrein 11,KLK 11 ELISA Kit |
CN-03728H2 |
ChemNorm |
48T |
EUR 320 |
Rat Interleukin 11,IL-11 ELISA KIT |
CN-01551R1 |
ChemNorm |
96T |
EUR 449 |
Rat Interleukin 11,IL-11 ELISA KIT |
CN-01551R2 |
ChemNorm |
48T |
EUR 299 |