Recurrent secondary genomic alterations in desmoplastic small round cell tumors.

Desmoplastic small round cell tumor (DSRCT) is a rare, highly aggressive, translocation-associated soft-tissue sarcoma that primarily affects children, adolescents, and young adults, with a striking male predominance. It is characterized by t(11;22) generating a novel EWSR1-WT1 fusion gene. Secondary genomic alterations are rarely described.Tumor tissue from 83 DSRCT patients was assayed by hybrid-capture based comprehensive genomic profiling, FoundationOne Heme next generation sequencing analysis of 406 genes and RNA sequencing of 265 genes.

Tumor mutation burden was calculated from a minimum of 1.4 Mb sequenced DNA. Microsatellite instability status was determined by a novel algorithm analyzing 114 specific loci.Comprehensive genomic profiling identified several genomically-defined DSRCT subgroups.

Recurrent genomic alterations were most frequently detected in FGFR4, ARID1A, TP53, MSH3, and MLL3 genes. With the exception of FGFR4, where the genomic alterations predicted activation, most of the alterations in the remaining genes predicted gene inactivation.

No DSRCT were TMB or MSI high.In summary, recurrent secondary somatic alterations in FGFR4, ARID1A, TP53, MSH3, and MLL3 were detected in 82% of DSRCT, which is significantly greater than previously reported. These alterations may have both prognostic and therapeutic implications.

HP, ID (HP, Haptoglobin, Zonulin, Haptoglobin alpha chain, Haptoglobin beta chain) (PE)
MBS6308209-5x02mL	MyBiosource	5x0.2mL	EUR 4250

HP, ID (HP, Haptoglobin, Zonulin, Haptoglobin alpha chain, Haptoglobin beta chain) (APC)
MBS6308200-02mL	MyBiosource	0.2mL	EUR 980

HP, ID (HP, Haptoglobin, Zonulin, Haptoglobin alpha chain, Haptoglobin beta chain) (APC)
MBS6308200-5x02mL	MyBiosource	5x0.2mL	EUR 4250

HP, ID (HP, Haptoglobin, Zonulin, Haptoglobin alpha chain, Haptoglobin beta chain) (FITC)
MBS6308202-02mL	MyBiosource	0.2mL	EUR 980

HP, ID (HP, Haptoglobin, Zonulin, Haptoglobin alpha chain, Haptoglobin beta chain) (FITC)
MBS6308202-5x02mL	MyBiosource	5x0.2mL	EUR 4250

HP, ID (HP, Haptoglobin, Zonulin, Haptoglobin alpha chain, Haptoglobin beta chain) (Biotin)
MBS6308201-02mL	MyBiosource	0.2mL	EUR 980

HP, ID (HP, Haptoglobin, Zonulin, Haptoglobin alpha chain, Haptoglobin beta chain) (Biotin)
MBS6308201-5x02mL	MyBiosource	5x0.2mL	EUR 4250

HP, ID (HP, Haptoglobin, Zonulin, Haptoglobin alpha chain, Haptoglobin beta chain) (Azide free) (HRP)
MBS6308203-02mL	MyBiosource	0.2mL	EUR 980

HP, ID (HP, Haptoglobin, Zonulin, Haptoglobin alpha chain, Haptoglobin beta chain) (Azide free) (HRP)
MBS6308203-5x02mL	MyBiosource	5x0.2mL	EUR 4250

HP, ID (HP, Haptoglobin, Zonulin, Haptoglobin alpha chain, Haptoglobin beta chain) (MaxLight 405)
MBS6308204-01mL	MyBiosource	0.1mL	EUR 980

HP, ID (HP, Haptoglobin, Zonulin, Haptoglobin alpha chain, Haptoglobin beta chain) (MaxLight 405)
MBS6308204-5x01mL	MyBiosource	5x0.1mL	EUR 4250

HP, ID (HP, Haptoglobin, Zonulin, Haptoglobin alpha chain, Haptoglobin beta chain) (MaxLight 490)
MBS6308205-01mL	MyBiosource	0.1mL	EUR 980

HP, ID (HP, Haptoglobin, Zonulin, Haptoglobin alpha chain, Haptoglobin beta chain) (MaxLight 490)
MBS6308205-5x01mL	MyBiosource	5x0.1mL	EUR 4250

HP, ID (HP, Haptoglobin, Zonulin, Haptoglobin alpha chain, Haptoglobin beta chain) (MaxLight 550)
MBS6308206-01mL	MyBiosource	0.1mL	EUR 980

HP, ID (HP, Haptoglobin, Zonulin, Haptoglobin alpha chain, Haptoglobin beta chain) (MaxLight 550)
MBS6308206-5x01mL	MyBiosource	5x0.1mL	EUR 4250

HP, ID (HP, Haptoglobin, Zonulin, Haptoglobin alpha chain, Haptoglobin beta chain) (MaxLight 650)
MBS6308207-01mL	MyBiosource	0.1mL	EUR 980

HP, ID (HP, Haptoglobin, Zonulin, Haptoglobin alpha chain, Haptoglobin beta chain) (MaxLight 650)
MBS6308207-5x01mL	MyBiosource	5x0.1mL	EUR 4250

HP, ID (HP, Haptoglobin, Zonulin, Haptoglobin alpha chain, Haptoglobin beta chain) (MaxLight 750)
MBS6308208-01mL	MyBiosource	0.1mL	EUR 980

HP, ID (HP, Haptoglobin, Zonulin, Haptoglobin alpha chain, Haptoglobin beta chain) (MaxLight 750)
MBS6308208-5x01mL	MyBiosource	5x0.1mL	EUR 4250

Haptoglobin Human (Haptoglobin Human)
PT_40803	Novatein Biosciences, Inc.	Ask for price Ask for price Ask for price	200 µg 1 mg 10 mg

Recombinant Haplopelma hainanum Hainantoxin-II.11
MBS1041230-005mgBaculovirus	MyBiosource	0.05mg(Baculovirus)	EUR 895

Recombinant Haplopelma hainanum Hainantoxin-II.11
MBS1041230-005mgEColi	MyBiosource	0.05mg(E-Coli)	EUR 520

Recombinant Haplopelma hainanum Hainantoxin-II.11
MBS1041230-005mgYeast	MyBiosource	0.05mg(Yeast)	EUR 715

Recombinant Haplopelma hainanum Hainantoxin-II.11
MBS1041230-02mgEColi	MyBiosource	0.2mg(E-Coli)	EUR 680

Recombinant Haplopelma hainanum Hainantoxin-II.11
MBS1041230-05mgEColi	MyBiosource	0.5mg(E-Coli)	EUR 725

Recombinant Haplopelma hainanum Hainantoxin-XVI.11
MBS1192657-005mgBaculovirus	MyBiosource	0.05mg(Baculovirus)	EUR 900

Recombinant Haplopelma hainanum Hainantoxin-XVI.11
MBS1192657-005mgEColi	MyBiosource	0.05mg(E-Coli)	EUR 520

Recombinant Haplopelma hainanum Hainantoxin-XVI.11
MBS1192657-005mgYeast	MyBiosource	0.05mg(Yeast)	EUR 720

Recombinant Haplopelma hainanum Hainantoxin-XVI.11
MBS1192657-02mgEColi	MyBiosource	0.2mg(E-Coli)	EUR 685

Recombinant Haplopelma hainanum Hainantoxin-XVI.11
MBS1192657-05mgEColi	MyBiosource	0.5mg(E-Coli)	EUR 730

Recombinant Haplopelma hainanum Hainantoxin-XI-11
MBS1230555-005mgBaculovirus	MyBiosource	0.05mg(Baculovirus)	EUR 910

Recombinant Haplopelma hainanum Hainantoxin-XI-11
MBS1230555-005mgEColi	MyBiosource	0.05mg(E-Coli)	EUR 540

Recombinant Haplopelma hainanum Hainantoxin-XI-11
MBS1230555-005mgYeast	MyBiosource	0.05mg(Yeast)	EUR 735

Recombinant Haplopelma hainanum Hainantoxin-XI-11
MBS1230555-02mgEColi	MyBiosource	0.2mg(E-Coli)	EUR 695

Recombinant Haplopelma hainanum Hainantoxin-XI-11
MBS1230555-05mgEColi	MyBiosource	0.5mg(E-Coli)	EUR 760

Recombinant Haplopelma hainanum Hainantoxin-II-11
MBS1020228-005mgBaculovirus	MyBiosource	0.05mg(Baculovirus)	EUR 895

Recombinant Haplopelma hainanum Hainantoxin-II-11
MBS1020228-005mgEColi	MyBiosource	0.05mg(E-Coli)	EUR 520

Recombinant Haplopelma hainanum Hainantoxin-II-11
MBS1020228-005mgYeast	MyBiosource	0.05mg(Yeast)	EUR 715

Recombinant Haplopelma hainanum Hainantoxin-II-11
MBS1020228-02mgEColi	MyBiosource	0.2mg(E-Coli)	EUR 680

Recombinant Haplopelma hainanum Hainantoxin-II-11
MBS1020228-05mgEColi	MyBiosource	0.5mg(E-Coli)	EUR 725

Recombinant Haplopelma hainanum Hainantoxin-VIII.11
MBS1072735-005mgBaculovirus	MyBiosource	0.05mg(Baculovirus)	EUR 895

Recombinant Haplopelma hainanum Hainantoxin-VIII.11
MBS1072735-005mgEColi	MyBiosource	0.05mg(E-Coli)	EUR 515

Recombinant Haplopelma hainanum Hainantoxin-VIII.11
MBS1072735-005mgYeast	MyBiosource	0.05mg(Yeast)	EUR 715

Recombinant Haplopelma hainanum Hainantoxin-VIII.11
MBS1072735-02mgEColi	MyBiosource	0.2mg(E-Coli)	EUR 680

Recombinant Haplopelma hainanum Hainantoxin-VIII.11
MBS1072735-05mgEColi	MyBiosource	0.5mg(E-Coli)	EUR 725

Recombinant Haplopelma hainanum Hainantoxin-XVI-11
MBS1208900-005mgBaculovirus	MyBiosource	0.05mg(Baculovirus)	EUR 900

Recombinant Haplopelma hainanum Hainantoxin-XVI-11
MBS1208900-005mgEColi	MyBiosource	0.05mg(E-Coli)	EUR 520

Recombinant Haplopelma hainanum Hainantoxin-XVI-11
MBS1208900-005mgYeast	MyBiosource	0.05mg(Yeast)	EUR 720

Recombinant Haplopelma hainanum Hainantoxin-XVI-11
MBS1208900-02mgEColi	MyBiosource	0.2mg(E-Coli)	EUR 685

Recombinant Haplopelma hainanum Hainantoxin-XVI-11
MBS1208900-05mgEColi	MyBiosource	0.5mg(E-Coli)	EUR 730

Recombinant Haplopelma hainanum Hainantoxin-III-11
MBS1048616-005mgBaculovirus	MyBiosource	0.05mg(Baculovirus)	EUR 895

Recombinant Haplopelma hainanum Hainantoxin-III-11
MBS1048616-005mgEColi	MyBiosource	0.05mg(E-Coli)	EUR 515

Recombinant Haplopelma hainanum Hainantoxin-III-11
MBS1048616-005mgYeast	MyBiosource	0.05mg(Yeast)	EUR 715

Recombinant Haplopelma hainanum Hainantoxin-III-11
MBS1048616-02mgEColi	MyBiosource	0.2mg(E-Coli)	EUR 675

Recombinant Haplopelma hainanum Hainantoxin-III-11
MBS1048616-05mgEColi	MyBiosource	0.5mg(E-Coli)	EUR 720

Haptoglobin (HP, BP, Haptoglobin alpha Chain, Haptoglobin beta Chain, HP2ALPHA2, HPA1S, MGC111141) (AP)
MBS6479474-02mL	MyBiosource	0.2mL	EUR 980

Haptoglobin (HP, BP, Haptoglobin alpha Chain, Haptoglobin beta Chain, HP2ALPHA2, HPA1S, MGC111141) (AP)
MBS6479474-5x02mL	MyBiosource	5x0.2mL	EUR 4250

Haptoglobin (HP, BP, Haptoglobin alpha Chain, Haptoglobin beta Chain, HP2ALPHA2, HPA1S, MGC111141) (PE)
MBS6479484-02mL	MyBiosource	0.2mL	EUR 980

Haptoglobin (HP, BP, Haptoglobin alpha Chain, Haptoglobin beta Chain, HP2ALPHA2, HPA1S, MGC111141) (PE)
MBS6479484-5x02mL	MyBiosource	5x0.2mL	EUR 4250

Recombinant Haplopelma hainanum Hainantoxin-XIII-11
MBS1113977-005mgBaculovirus	MyBiosource	0.05mg(Baculovirus)	EUR 900

Recombinant Haplopelma hainanum Hainantoxin-XIII-11
MBS1113977-005mgEColi	MyBiosource	0.05mg(E-Coli)	EUR 525

Recombinant Haplopelma hainanum Hainantoxin-XIII-11
MBS1113977-005mgYeast	MyBiosource	0.05mg(Yeast)	EUR 720

Recombinant Haplopelma hainanum Hainantoxin-XIII-11
MBS1113977-02mgEColi	MyBiosource	0.2mg(E-Coli)	EUR 685

Recombinant Haplopelma hainanum Hainantoxin-XIII-11
MBS1113977-05mgEColi	MyBiosource	0.5mg(E-Coli)	EUR 735

Recombinant Haplopelma hainanum Hainantoxin-VIII-11
MBS1012886-005mgBaculovirus	MyBiosource	0.05mg(Baculovirus)	EUR 895

Recombinant Haplopelma hainanum Hainantoxin-VIII-11
MBS1012886-005mgEColi	MyBiosource	0.05mg(E-Coli)	EUR 515

Recombinant Haplopelma hainanum Hainantoxin-VIII-11
MBS1012886-005mgYeast	MyBiosource	0.05mg(Yeast)	EUR 715

Recombinant Haplopelma hainanum Hainantoxin-VIII-11
MBS1012886-02mgEColi	MyBiosource	0.2mg(E-Coli)	EUR 680

Recombinant Haplopelma hainanum Hainantoxin-VIII-11
MBS1012886-05mgEColi	MyBiosource	0.5mg(E-Coli)	EUR 725

Haptoglobin (HP, BP, Haptoglobin alpha Chain, Haptoglobin beta Chain, HP2ALPHA2, HPA1S, MGC111141) (APC)
MBS6479475-02mL	MyBiosource	0.2mL	EUR 980

Haptoglobin (HP, BP, Haptoglobin alpha Chain, Haptoglobin beta Chain, HP2ALPHA2, HPA1S, MGC111141) (APC)
MBS6479475-5x02mL	MyBiosource	5x0.2mL	EUR 4250

Haptoglobin (HP, BP, Haptoglobin alpha Chain, Haptoglobin beta Chain, HP2ALPHA2, HPA1S, MGC111141) (Biotin)
MBS6479476-02mL	MyBiosource	0.2mL	EUR 980

Haptoglobin (HP, BP, Haptoglobin alpha Chain, Haptoglobin beta Chain, HP2ALPHA2, HPA1S, MGC111141) (Biotin)
MBS6479476-5x02mL	MyBiosource	5x0.2mL	EUR 4250

Haptoglobin (HP, BP, Haptoglobin alpha Chain, Haptoglobin beta Chain, HP2ALPHA2, HPA1S, MGC111141) (FITC)
MBS6479477-02mL	MyBiosource	0.2mL	EUR 980

Haptoglobin (HP, BP, Haptoglobin alpha Chain, Haptoglobin beta Chain, HP2ALPHA2, HPA1S, MGC111141) (FITC)
MBS6479477-5x02mL	MyBiosource	5x0.2mL	EUR 4250

Hapten/ Hapten-HRP-conjugate stabilizer
DPHHRPG-100mL	Diagnopal	100 mL	EUR 59.28

Hapten/ Hapten-HRP-conjugate stabilizer
DPHHRPG-1Liter	Diagnopal	1 Liter	EUR 178.6

Haptoglobin (HP, BP, Haptoglobin alpha Chain, Haptoglobin beta Chain, HP2ALPHA2, HPA1S, MGC111141) (Azide free) (HRP)
MBS6479478-02mL	MyBiosource	0.2mL	EUR 980

Haptoglobin (HP, BP, Haptoglobin alpha Chain, Haptoglobin beta Chain, HP2ALPHA2, HPA1S, MGC111141) (Azide free) (HRP)
MBS6479478-5x02mL	MyBiosource	5x0.2mL	EUR 4250

Haptoglobin (HP, BP, Haptoglobin alpha Chain, Haptoglobin beta Chain, HP2ALPHA2, HPA1S, MGC111141) (MaxLight 405)
MBS6479479-01mL	MyBiosource	0.1mL	EUR 980

Haptoglobin (HP, BP, Haptoglobin alpha Chain, Haptoglobin beta Chain, HP2ALPHA2, HPA1S, MGC111141) (MaxLight 405)
MBS6479479-5x01mL	MyBiosource	5x0.1mL	EUR 4250

Haptoglobin (HP, BP, Haptoglobin alpha Chain, Haptoglobin beta Chain, HP2ALPHA2, HPA1S, MGC111141) (MaxLight 490)
MBS6479480-01mL	MyBiosource	0.1mL	EUR 980

Haptoglobin (HP, BP, Haptoglobin alpha Chain, Haptoglobin beta Chain, HP2ALPHA2, HPA1S, MGC111141) (MaxLight 490)
MBS6479480-5x01mL	MyBiosource	5x0.1mL	EUR 4250

Haptoglobin (HP, BP, Haptoglobin alpha Chain, Haptoglobin beta Chain, HP2ALPHA2, HPA1S, MGC111141) (MaxLight 550)
MBS6479481-01mL	MyBiosource	0.1mL	EUR 980

Haptoglobin (HP, BP, Haptoglobin alpha Chain, Haptoglobin beta Chain, HP2ALPHA2, HPA1S, MGC111141) (MaxLight 550)
MBS6479481-5x01mL	MyBiosource	5x0.1mL	EUR 4250

Haptoglobin (HP, BP, Haptoglobin alpha Chain, Haptoglobin beta Chain, HP2ALPHA2, HPA1S, MGC111141) (MaxLight 650)
MBS6479482-01mL	MyBiosource	0.1mL	EUR 980

Haptoglobin (HP, BP, Haptoglobin alpha Chain, Haptoglobin beta Chain, HP2ALPHA2, HPA1S, MGC111141) (MaxLight 650)
MBS6479482-5x01mL	MyBiosource	5x0.1mL	EUR 4250

Haptoglobin (HP, BP, Haptoglobin alpha Chain, Haptoglobin beta Chain, HP2ALPHA2, HPA1S, MGC111141) (MaxLight 750)
MBS6479483-01mL	MyBiosource	0.1mL	EUR 980

Haptoglobin (HP, BP, Haptoglobin alpha Chain, Haptoglobin beta Chain, HP2ALPHA2, HPA1S, MGC111141) (MaxLight 750)
MBS6479483-5x01mL	MyBiosource	5x0.1mL	EUR 4250

Haptoglobin Human Recombinant (Haptoglobin Human)
PT_40804	Novatein Biosciences, Inc.	Ask for price Ask for price Ask for price	5 µg 20 µg 1 mg

Rabbit Polyclonal antibody to Haptoglobin (haptoglobin)
TA308899	Origene Technologies GmbH	100 µl	Ask for price

Rabbit Polyclonal antibody to Haptoglobin (haptoglobin)
TA308900	Origene Technologies GmbH	100 µl	Ask for price

Interleukin-11 (IL-11)
GWB-867D56	GenWay Biotech	0.01 mg	Ask for price

MitoBloCK-11 (MB-11)
MBS5764963-10mg	MyBiosource	10mg	EUR 470

MitoBloCK-11 (MB-11)
MBS5764963-1mg	MyBiosource	1mg	EUR 210

MitoBloCK-11 (MB-11)
MBS5764963-25mg	MyBiosource	25mg	EUR 780

MitoBloCK-11 (MB-11)
MBS5764963-50mg	MyBiosource	50mg	EUR 1130

MitoBloCK-11 (MB-11)
MBS5764963-5mg	MyBiosource	5mg	EUR 335

Interleukin-11 (IL-11)
MBS590016-192Wells	MyBiosource	192Wells	EUR 995

Interleukin-11 (IL-11)
MBS590016-3x192Wells	MyBiosource	3x192Wells	EUR 2315

Interleukin-11 (IL-11)
MBS590016-96Wells	MyBiosource	96Wells	EUR 660

MitoBloCK-11 (MB-11)
T8782-10mg	TargetMol Chemicals	10mg	Ask for price
Description: MitoBloCK-11 (MB-11)

MitoBloCK-11 (MB-11)
T8782-1g	TargetMol Chemicals	1g	Ask for price
Description: MitoBloCK-11 (MB-11)

MitoBloCK-11 (MB-11)
T8782-1mg	TargetMol Chemicals	1mg	Ask for price
Description: MitoBloCK-11 (MB-11)

MitoBloCK-11 (MB-11)
T8782-50mg	TargetMol Chemicals	50mg	Ask for price
Description: MitoBloCK-11 (MB-11)

MitoBloCK-11 (MB-11)
T8782-5mg	TargetMol Chemicals	5mg	Ask for price
Description: MitoBloCK-11 (MB-11)

OPPA01435-200UG - Haptoglobin Human - Human Haptoglobin Protein
OPPA01435-200UG	Aviva Systems Biology	200ug	EUR 112

Haptamide B
MBS5775214-5mg	MyBiosource	5(mg	EUR 915

Haptamide B
MBS5775214-5x5mg	MyBiosource	5x5(mg	EUR 3970

Haptamide B
T25488-10mg	TargetMol Chemicals	10mg	Ask for price
Description: Haptamide B

Haptamide B
T25488-1g	TargetMol Chemicals	1g	Ask for price
Description: Haptamide B

Haptamide B
T25488-1mg	TargetMol Chemicals	1mg	Ask for price
Description: Haptamide B

Haptamide B
T25488-50mg	TargetMol Chemicals	50mg	Ask for price
Description: Haptamide B

Haptamide B
T25488-5mg	TargetMol Chemicals	5mg	Ask for price
Description: Haptamide B

Haptoglobin
AP78677	SAB	1mg	EUR 2640

Hp | Haptoglobin
AS10-1312	Agrisera AB	1 mg	EUR 233

Haptoglobin
AP83683	SAB	1mg	EUR 2640

Haptoglobin
AP83875	SAB	1mg	EUR 2640

Haptoglobin
AP83959	SAB	1mg	EUR 2640

Haptoglobin
AP84082	SAB	1mg	EUR 2640